This code defines a Python function named `dna2aa` that translates...

August 29, 2025 at 06:54 AM

def dna2aa(dna_str): aa_str = "" for i in range(0, len(dna_str), 3): codon = dna_str[i:i+3] aa = codon2aa.get(codon, "X") aa_str += aa return aa_str

This code defines a Python function named dna2aa that translates a DNA sequence (string) into a corresponding amino acid sequence (string) using codons.

Explanation:

  1. Input: The function takes one argument, dna_str, which is a string representing a DNA sequence consisting of nucleotide bases (A, T, C, G).

  2. Output: The function returns a string, aa_str, which represents the amino acid sequence derived from the DNA sequence.

  3. Logic Breakdown:

    • aa_str = "": Initializes an empty string to build the translated amino acid sequence.
    • for i in range(0, len(dna_str), 3): Iterates through the DNA sequence in chunks (frames) of 3 nucleotides (which form a codon).
    • codon = dna_str[i:i+3]: Extracts a codon (group of 3 nucleotides).
    • aa = codon2aa.get(codon, "X"): Looks up the amino acid corresponding to this codon in a dictionary codon2aa.
      • If the codon is not found in the dictionary, it defaults to "X" (unknown amino acid).
    • aa_str += aa: Appends the derived amino acid to the aa_str.
  4. Return Statement: After processing all codons, the function returns the full amino acid sequence.

Assumptions:

  • codon2aa is assumed to be a predefined dictionary that maps 3-letter DNA codons to their respective single-letter amino acid codes. For example, {'ATG': 'M', 'TGG': 'W', 'TAA': '*', ...}.
  • If the DNA sequence length is not a multiple of 3, the last one or two remaining bases will be ignored because slicing (dna_str[i:i+3]) stops at the end of the string.

Example Usage:

codon2aa = {
    'ATG': 'M', 'TGG': 'W', 'TAA': '*', 'TAG': '*', 'TGA': '*',
    'GCT': 'A', 'GCC': 'A', 'GCA': 'A', 'GCG': 'A'
    # More codons...
}

dna_sequence = "ATGGCTTAA"
amino_acid_sequence = dna2aa(dna_sequence)
print(amino_acid_sequence)
# Output: "MA*"

Summary:

The dna2aa function performs codon-to-amino-acid translation of a DNA sequence using a codon lookup dictionary (codon2aa) and returns the corresponding amino acid sequence.

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