This code is a snippet from a dynamic programming algorithm,...
September 1, 2025 at 12:03 PM
This code is a snippet from a dynamic programming algorithm, likely related to sequence alignment, such as the Needleman-Wunsch or Smith-Waterman algorithm, commonly used in bioinformatics.
What the code does:
-
Compute the value for a cell (
S[i, j]
): The value ofS[i, j]
is determined as the maximum score among:match
: The score when the characters at current positions of the sequences are aligned (either matched or mismatched).delete
: The score when there is a gap in one sequence, corresponding to a deletion.insert
: The score when there is a gap in the other sequence, corresponding to an insertion.
-
Set the traceback information (
trace[i, j, :]
): Based on which operation (match, delete, or insert) contributed to the maximum score inS[i, j]
, the algorithm updates thetrace
array to indicate the direction of traceback:- If the
match
score was the maximum,trace[i, j, :]
is set to(-1, -1, 0)
:- This indicates a diagonal move for a match/mismatch (both sequences move one step back:
i - 1
andj - 1
).
- This indicates a diagonal move for a match/mismatch (both sequences move one step back:
- If the
delete
score was the maximum,trace[i, j, :]
is set to(-1, 0, 0)
:- This indicates an upward move for a gap in the second sequence (move back in the first sequence:
i - 1
, no change inj
).
- This indicates an upward move for a gap in the second sequence (move back in the first sequence:
- If the
insert
score was the maximum,trace[i, j, :]
is set to(0, -1, 0)
:- This indicates a leftward move for a gap in the first sequence (move back in the second sequence:
j - 1
, no change ini
).
- This indicates a leftward move for a gap in the first sequence (move back in the second sequence:
- If the
Purpose of the Code:
This code forms a part of the scoring and traceback matrix computation, which are core steps in sequence alignment algorithms. Specifically:
- The
S
matrix represents the alignment scores. - The
trace
matrix is used later during a traceback step to reconstruct the optimal alignment path between the two sequences based on the score matrix and chosen move directions.
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